Elise Braatz, BS Neuroscience, The College of William and Mary
Research in the Zeitlin lab focuses on Huntington’s disease, a hereditary disorder that produces progressive motor, cognitive, and behavioral deficits in those affected. Huntington's disease is caused by a lengthened polyglutamine stretch in the protein huntingtin. This mutation triggers neurodegeneration in the striatum and cortex. My project involves determining the functional importance of specific regions of huntingtin, including the polyglutamine repeat, both in health and disease. To accomplish this, I am performing behavioral, cellular, and molecular analyses on transgenic mouse models developed in this lab.