Joe (Ogochukwu) Uweru

Eyo (pronounced as “A-YO”) Lab

Broadly speaking, Eyo Lab is interested in understanding the role(s) of microglia in neurodevelopment and neurodevelopmental disorders such as febrile seizure and Autism Spectrum Disorder (ASD). Based on these themes, I am currently working on two projects in the lab, one seeks to determine the role of microglia in Autism Spectrum Disorder (ASD) using the maternal immune activation model in mice. More specifically, this project aims to delineate the potential role of microglial P2Y12 receptor in autism. My second project aims to elucidate the underlying mechanism(s) of microglial phagocytic clearance of cellular debris in the subgranular zone (SGZ) of the dentate gyrus during postnatal development. Moreover, I am also interested in determining the significance of microglial phagocytic clearance in the brain, especially in relation to neurogenesis.