Joshua Milstein

Type 2 Diabetes (T2D) is a metabolic disease largely characterized by the body's inability to respond normally to insulin, a process commonly referred to as insulin resistance. Recent evidence suggests that T2D not only affects peripheral metabolism, but also impairs cognitive function and metabolism in the brain. However, how obesity-induced T2D affects metabolism in the brain has not been well-characterized. My research aims to address this connection in a cell-type-specific manner using novel in vivo and in vitro models. In particular, I am interested in the mitochondrial abnormalities that may arise in both neurons and glia as a result of obesity-induced insulin resistance.