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John Lukens

John Lukens, 2023
Associate Professor, Department of Neuroscience

Research Disciplines: Neuroimmunology, Neurodegenerative Disease, Neurodevelopmental Disease, Glial Biology

Research Interests: Alzheimer’s disease, multiple sclerosis, traumatic brain injury, autism, microglia, neuroinflammation

Research Description: Our lab is investigating how innate immune signaling contributes to neurodegenerative, demyelinating, and neurodevelopmental disorders. We believe that a more complete characterization of the interactions between the immune and nervous systems will lead to improved understanding of complex neurological disorders in humans and will help to identify novel and promising therapeutic targets to treat CNS diseases. 

Selected Publications: 

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model | Proceedings of the National Academy of Sciences

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis - Nature Communications

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment