Research Disciplines: neonatal brain injury

Research Interests: neonatal hypoxic-ischemic encephalopathy, neonatal seizures

Research Description: Our lab uses a mouse model to investigate how early life injury and seizures lead to changes in brain development and later behavioral and cognitive deficits. Techniques include neonatal mouse electroencephalography, immunohistochemistry, confocal imaging and analysis, behavior. 

Selected Publications: 

1: Burnsed J, Matysik W, Yang L, Sun H, Joshi S, Kapur J. Increased glutamatergic synaptic transmission during development in layer II/III mouse motor cortex pyramidal neurons. Cereb Cortex. 2023 Apr 4;33(8):4645-4653. doi: 10.1093/cercor/bhac368. PMID: 36137566; PMCID: PMC10110452.

2: Mazurkiewicz M, Kambham A, Pace B, Skwarzynska D, Wagley P, Burnsed J. Neuronal activity mapping during exploration of a novel e vironment. Brain Res. 2022 Feb 1;1776:147748. doi: 10.1016/j.brainres.2021.147748. Epub 2021 Dec 9. PMID: 34896333; PMCID: PMC8728889.

3: Wagley PK, Williamson J, Skwarzynska D, Kapur J, Burnsed J. Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice. J Vis Exp. 2020 Jun 11;(160):10.3791/61346. doi: 10.3791/61346. PMID: 32597865; PMCID: PMC7895489.

4: Burnsed J, Skwarzyńska D, Wagley PK, Isbell L, Kapur J. Neuronal Circuit Activity during Neonatal Hypoxic-Ischemic Seizures in Mice. Ann Neurol. 2019 Dec;86(6):927-938. doi: 10.1002/ana.25601. Epub 2019 Oct 18. PMID: 31509619; PMCID: PMC7025736