Neurodegeneration and TBI

Axon degeneration is a hallmark of pathological insult, such as injury or disease, and often precedes loss of neuronal function. Since the 1850s it has been appreciated that such degeneration occurs across species, from worms to humans, however, we still know very little about the mechanisms governing axon degeneration.   Given that degeneration of synapses and axons is often among the earliest events associated with degenerative disorders such as Alzheimer’s and Parkinson’s disease, preservation of these axons represents an important therapeutic strategy.  The UVa NGP is at the forefront of understanding the mechanisms of neurodegeration, which is allowing us to rationalize better treatments.  We have concentrations of investigators studying neurodegenerative disease (Alzheimer's, Huntington's) as well as degeneration after injury (ie spinal cord injury or traumatic brain injury).

Affiliated Faculty

Kevin Lee
Jim Mandell