Neurophysiology: from ion channels to circuits

One of the core strengths of UVa neuroscience is a collaborative environment with labs investigating the micro (ie intrinsic properties of ion channels) and macro aspects of nervous system function (ie circuit neurophysiology). Each level of analysis contributes critical information to our understanding of neural function, as well as pathological scenarios such as epilepsy, eating disorders and intellectual disability. An integrative question requires an integrative approach. As such, we tackle these problems using cutting edge genetic, biochemical, and electrophysiological techniques. The labs that are particularly interested in these questions include:  

Relevant Faculty:

  • Mark Beenhakker - Circuit mechanisms of sleep and epilepsy
  • Manoj Patel - Physiology of sodium voltage-gated channels
  • Patrice Guyenet - Neural control of blood pressure and respiration
  • Ed Bertram - Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology
  • Doug Baylis - Mechanisms of neuromodulation in central neurons
  • Ed Perez-Reyes - Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies
  • Jaideep Kapur - Pathophysiology of Status Epilepticus; Plasticity of GABAergic Synaptic Transmission
  • Dan Meliza - Neural Mechanisms of Pattern Learning and Recognition in the Auditory System
  • Julius Zhu - Neural Circuits in Healthy and Diseased Brains
  • Jeff Corwin - Regeneration and Developmental Biology of the Hearing and Balance Organs in the Vertebrate Ear
  • Jung-Bum Shin - Auditory Neurobiology
  • Kevin Lee - Neuronal Vulnerability: A Study of Cellular Mechanism